Regeneration Project I
CAXXÖN LABS have created several patented technology boosting up the leap of bio-regeneration.
Aging Skin Regeneration (AGR)
The characteristic features of aging skin include wrinkles, dryness of the skin, reduced skin thickness, loss of elasticity, dermal and epidermal atrophy, reduced rate of epidermal cell proliferation and cellular senescence. External factors that mainly contribute to skin aging include sunlight, UV radiation, chemicals, pollutants, and smoking. Besides external stimuli, endogenous processes that trigger aging process include excessive free radical production, nuclear/mitochondrial gene mutation, cellular senescence, shortening of telomere, reduced cell proliferation, and impaired immune functioning. In recent years, many scientific studies have revealed that advanced glycation end products (AGEs) are also among the crucial contributory factors of skin aging.
Accumulation of AGEs in the skin has been observed both in diabetes and during chronological aging. Proteins with slow turnover rate, such as collagen I and IV, as well as long-lived proteins, such as fibronectin, are primary targets of glycation reaction in the skin. Moreover, excessive deposition of AGEs in sun-exposed skin areas suggests that solar radiation, especially UV radiation, may play an important role in the formation of AGEs. Apart from sunlight, other external factors that are responsible for increased formation and deposition of AGEs in the skin include smoking and diet. The amount of AGEs in the food mainly depends on the method of preparation. For example, fried foods contain higher amount of AGEs as compared to boiled foods. About 10-30% of ingested AGEs are absorbed in the body and may participate in skin aging. Mechanistically, AGEs can react with proteins, lipids, and nucleic acids and alter their normal physiological functioning. Upon binding to their receptors, AGEs can also trigger a cascade of signaling pathways, leading to reduced cell proliferation, increase cellular senescence and apoptosis, decreased extracellular matrix synthesis, increased formation of free radicals and pro-inflammatory mediators, etc. All these processes can potentially contribute to skin aging.
Strategies to Control AGEs Since autofluorescence is an intrinsic property of AGEs, measurement of skin fluorescence is an effective method of detecting AGE deposition in the skin. Studies have found that skin fluorescence positively correlates with many age-related disorders, such as cardiovascular diseases, renal disorder, macular degeneration, and overall mortality. Given the immense involvement of AGEs in age-related disorders, including skin aging, effective strategies/interventions are needed to prevent, or at least control, their accumulation in the body. In this regard, most efficient strategies include removal of already formed AGEs from the body by degrading glycated proteins; inhibiting the formation of AGEs; and antagonizing AGE-mediated signaling cascade.
Harvard Dutta, Sanchari Sinha. 2018. Glycation and Skin Aging. News-Medical, viewed 03 January 2021, https://www.news-medical.net/health/Glycation-and-Skin-Aging.aspx.